| 9AP | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Macros | ⊕ United States | Assembler autocode for the 709/0 |
| A9 | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Low-level Autocoders | ⊕ Australia | Interpreter for SILLIAC |
| ACOMCAS | 1959 | ↓ ↑ ⊕ Multi-purpose | ⊕ Low-level Autocoders | ⊕ United States | Autocoder for UNIVAC |
| ACSI-Matic | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ COBOL coeval | ⊕ United States | Associative query language |
| ALGOL 60 | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ True ALGOL60s | ⊕ International | Algorithm Language |
| Algol 60 Publishing | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ True ALGOL60s | ⊕ International | Typographically rich form of Algol 60 |
| Alphacode | 1959 | ↓ ↑ ⊕ Multi-purpose | ⊕ Early Autocodes | ⊕ United Kingdom | High level autocode for English Electric Deuce |
| ALTAC | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Fortran I-III Variants | ⊕ United States | Algorithms on TAC |
| ANCP | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Autocode Coeval | ⊕ United States | Datatron autocode |
| APG-1 | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ Other DPLs | ⊕ United States | Dupont business oriented language |
| APL | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Generalised programming | ⊕ United States | Automatic Programming Language |
| APX III | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | Datatron autocode |
| AS Intercode | 1959 | ↓ ↑ ⊕ Multi-purpose | ⊕ Early Autocodes | ⊕ United Kingdom | Port of Intercode to run at Armstrong Siddley |
| BASIC AUTOCODER | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | Simplified AUTOCODER |
| Bell SAP | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Macroassemblers | ⊕ United States | SAP with conditional and recursive macros |
| BNF | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Grammar and Syntax-oriented | ⊕ United States | Backus Naur Form |
| Calculus | 1959 | ⊕ Fortran I-III Coeval | ⊕ United States | Compiler at CASE | |
| CAP | 1959 | ⊕ Symbolic assemblers | ⊕ United States | Cornell Assembler | |
| CODEL | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ Early Autocodes | ⊕ United Kingdom | Autocoder from ICT |
| Commercial Translator | 1959 | ⊕ COBOL coeval | ⊕ United States | ||
| D-0 | 1959 | ⊕ COBOL coeval | ⊕ United States | ||
| DAISY 201 | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | G-15 Autocoder |
| DART | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Strict Early Fortrans | ⊕ United States | Simplified FORTRAN + brackets |
| DEPI 4 | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Differential Equations | ⊕ United States | Continuous simulation language |
| DOW COMPILER | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | Dow Chemicals Autocoder |
| DYNAMO | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Expression oriented | ⊕ United States | DYNAmic MOdels simulation |
| ERFPI | 1959 | ⊕ United States | |||
| FAP | 1959 | ⊕ Symbolic assemblers | ⊕ United States | FORTRAN Assembly Program | |
| FAST | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Fortran I-III Variants | ⊕ United States | FORTRAN compiler |
| FLIP | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ List | ⊕ Australia | Functional list processor |
| FORTRUNCIBLE | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Autocode Coeval | ⊕ United States | FORTRAN/RUNCIBLE |
| GAT | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Internal Translators | ⊕ United States | Generalized Algebraic Translator |
| GEPURS | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | General purpose autocoder |
| Gordon Simulator | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Activity scanning | ⊕ United States | Systems simulation dialect of FORTRAN |
| GPSS | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Event scheduling | ⊕ United States | General Purpose Systems Simulator |
| HAYSTAQ | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ Ad hoc query languages | ⊕ United States | Restricted input querying language |
| Ingerman generalised BNF | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ United States | ||
| INTERCOM 1000 | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Low-level Autocoders | ⊕ United States | Autocode for the Bendix G-15 |
| Intrinsic | 1959 | ⊕ United Kingdom | |||
| JAZ | 1959 | ⊕ Low-level Autocoders | ⊕ United States | Autocode for Royal McBee | |
| JOVIAL | 1959 | ↓ ↑ ⊕ Multi-purpose | ⊕ Jovials | ⊕ United States | Airforce International Algebraic Language |
| Kanner algebraic translator | 1959 | ⊕ Fortran I-III Coeval | ⊕ United States | Algebraic translation system | |
| KISS | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ High-level Autocoders | ⊕ United States | Chrysler 650 Autocode |
| Linear lisp | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ Lazy Evaluation LISPs | ⊕ United States | |
| LISP 1.5 | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ Lazy Evaluation LISPs | ⊕ United States | LISP major release |
| LT-2 | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Linear | ⊕ United States | |
| Macro SAP | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ Macroassemblers | ⊕ United States | Macro compiler modification of SAP |
| MAD | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ United States | Michigan Algorithm Decoder | |
| Micro-flowcharts | 1959 | ||||
| MUSE | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ High-level Autocoders | ⊕ United States | Modified USE |
| N1 | 1959 | ⊕ Other lambda | ⊕ Italy | Olivetti's non-procedural language | |
| Nugent IR language | 1959 | ||||
| ORBIT | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Internal Translators | ⊕ United States | Oak Ridge IT |
| Pegasus AUTOCODE | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Early Autocodes | ⊕ United Kingdom | Autocode for the Pegasus system |
| Pegasus function interpreter | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Algebraic | ⊕ United Kingdom | Algebraic system for the Pegasus |
| Perlis and Evans multilevel system | 1959 | ||||
| POGO | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Low-level Autocoders | ⊕ United States | G-15 Autocoder |
| Polynomial PRORAB | 1959 | ⊕ Algebraic | ⊕ Russian Federation | ||
| Q-0 | 1959 | ⊕ COBOL coeval | ⊕ United States | ||
| RPG | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ Report Generators | ⊕ United States | Report Program Generator |
| SALE | 1959 | ↓ ↑ ⊕ Numerical Scientific | ⊕ Fortran I-III Coeval | ⊕ United States | Algorithmic language for Engineers |
| SCAD | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Multiline | ⊕ United States | Grems/Post document access language |
| Sequence Diagram Simulator | 1959 | ⊕ Activity scanning | ⊕ United States | Early diagramatic simulator | |
| SHADOW II | 1959 | ⊕ Grammar and Syntax-oriented | ⊕ United States | Syntax-directed compiler | |
| SHARE Information Algebra | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Other DPLs | ⊕ United States | Description language for inhomogeneous collection of entities |
| SHELL | 1959 | ⊕ Low-level Autocoders | ⊕ United States | Datatronic autocoder | |
| SIMCOM | 1959 | ↓ ↑ ⊕ Specialised Languages | ⊕ Process interaction | ⊕ United States | Simulation compiler |
| SMASHT | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Macroassemblers | ⊕ United States | SDC symbolic assembler |
| SOAP H | 1959 | ⊕ Symbolic assemblers | ⊕ United States | ||
| SPAR | 1959 | ⊕ Low-level Autocoders | ⊕ United States | Autocoder for Burroughs/Datatron 200 series | |
| SPEED | 1959 | ⊕ Low-level Autocoders | ⊕ United States | Autocode for LGP-30 | |
| SPEEDEX | 1959 | ⊕ Symbolic assemblers | ⊕ United States | Assembler for 701 | |
| Spool | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Autocode Coeval | ⊕ United States | |
| SPUD | 1959 | ↓ ↑ ⊕ On-Line | ⊕ Other Conversational | ⊕ United States | Demonstration language |
| STAR I | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Symbolic assemblers | ⊕ United States | Burroughs 220 assembler |
| STEVE | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Early Autocodes | ⊕ United Kingdom | Symbolic language for the DEUCE |
| TAC | 1959 | ↓ ↑ ⊕ Business Data Processing | ⊕ Symbolic assemblers | ⊕ United States | TRANSAC Assembler Compiler |
| TAP | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Symbolic assemblers | ⊕ United States | TRANSAC symbolic assembler |
| TASS | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Symbolic assemblers | ⊕ United States | Tech Assembly System |
| TASS I | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Autocode Coeval | ⊕ United States | Autocoder for 650 |
| The Conversational Machine | 1959 | ⊕ United States | |||
| THREADED LISTS | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ List | ⊕ United States | List-processing language |
| TRAC | 1959 | ↓ ↑ ⊕ String and List Processing | ⊕ Macros | ⊕ United States | A man-machine string manipulating language |
| TRAWL | 1959 | ⊕ Lines | ⊕ United States | Read and write sublanguage | |
| TUFF/TUG | 1959 | ⊕ United States | |||
| TUG Algol | 1959 | ↓ ↑ ⊕ Multi-purpose | ⊕ Other IAL Coeval | ⊕ United States | TRANSAC IAL |
| Wegstein algebraic language | 1959 | ⊕ Intermediate languages and VMs | ⊕ United States | Intermediate language | |
| X-6 | 1959 | ↓ ↑ ⊕ Excluded from Sammet | ⊕ Macroassemblers | ⊕ United States |