| ABLE | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ List | ⊕ United States | Array-enabled LISP |
| ALGOL C | 1981 | ↓ ↑ ⊕ Numerical Scientific | ⊕ True ALGOL60s | ⊕ United Kingdom | Cambridge educational Algol 60 |
| AuditComputer | 1981 | ⊕ United States | |||
| BIGMAC | 1981 | ||||
| BOLT | 1981 | ||||
| Capsule | 1981 | ⊕ United States | Modular extensions to Pascal | ||
| CDLM | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Digital | ⊕ Germany | |
| CHI | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Description languages | ⊕ United States | Logic-based system for transformations |
| CLG | 1981 | ⊕ United States | Command Language Grammar | ||
| Common LISP | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ Lazy Evaluation LISPs | ⊕ United States | Consensus-based common dialect of LISP |
| CONCISE | 1981 | ⊕ United States | |||
| CONCUR | 1981 | ||||
| Consul | 1981 | ⊕ United States | |||
| COPAS | 1981 | ↓ ↑ ⊕ On-Line | ⊕ Pascals | ⊕ United Kingdom | Conversational Pascal |
| Cospol | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ United Kingdom | Dialect of CSP | |
| CPL | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ United States | Primos command language | |
| DCML | 1981 | ||||
| DCSL | 1981 | ||||
| DIANA | 1981 | ⊕ United States | Descriptive Intermediate Attributed Notation for Ada | ||
| DISCO | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Hybrid | ⊕ Denmark | Simulation language |
| Dislang | 1981 | ||||
| DISPEL | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ United States | Run-Time Debugging Language | |
| DIST | 1981 | ||||
| DL1 | 1981 | ⊕ United Kingdom | |||
| Elle | 1981 | ⊕ Italy | |||
| EPILOG | 1981 | ||||
| Eva | 1981 | ↓ ↑ ⊕ Multi-purpose | |||
| FLAN | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Vector | ⊕ United States | Vector processing language |
| FLIP | 1981 | ⊕ France | |||
| FOCAL-81 | 1981 | ↓ ↑ ⊕ On-Line | ⊕ Generation of JOSS I | ⊕ United States | 1981 version of FOCAL |
| GENglish | 1981 | ||||
| GIRL | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ 2d shape | ⊕ United States | Graphical input language |
| GML | 1981 | ||||
| GORDAS | 1981 | ||||
| GPL | 1981 | ⊕ United States | Graphical Data-driven Programming language | ||
| GRUNCH | 1981 | ||||
| HDDL | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Netherlands | Philips dialogue definition language | |
| HIBOL | 1981 | ↓ ↑ ⊕ Business Data Processing | ⊕ United States | High Level COBOL | |
| HLL | 1981 | ⊕ United States | |||
| HYBSIS | 1981 | ⊕ 2d shape | ⊕ Austria | Graphical simulation system | |
| IDL | 1981 | ||||
| IDMS | 1981 | ↓ ↑ ⊕ Experimental and other | ⊕ 2d shape | ⊕ United States | Pictorial query language |
| IF | 1981 | ||||
| IMPS | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ Pascals | ⊕ United States | Pascal module-capable dialect |
| Interlisp-VAX | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ Lazy Evaluation LISPs | ⊕ United States | |
| IPSS/Rel | 1981 | ⊕ 2d shape | ⊕ United States | Simulation language | |
| ITL | 1981 | ⊕ United Kingdom | |||
| Karel | 1981 | ⊕ United States | |||
| Karlsruhe AL | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Germany | Karlsruhe version of AL | |
| KBS | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Event scheduling | ⊕ United States | Frames-based simulation language |
| KRC | 1981 | ⊕ United Kingdom | Kent Recursive Calculator | ||
| LOGO-S | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ United States | Proposed standard LOGO | |
| LPL | 1981 | ⊕ Sweden | Logic Programming Language | ||
| LPL0 | 1981 | ⊕ Sweden | |||
| LZ | 1981 | ⊕ United States | |||
| MAD | 1981 | ||||
| MAMONT | 1981 | ⊕ Russian Federation | |||
| microAPL | 1981 | ↓ ↑ ⊕ Experimental and other | ⊕ Array | ⊕ United States | Microprogramming APL Dialect |
| Micro-Dynamo | 1981 | ⊕ United States | |||
| micro-PRL | 1981 | ⊕ United States | |||
| microTAL | 1981 | ⊕ United States | |||
| MIDL | 1981 | ⊕ Netherlands | MicroInstruction Description Language. | ||
| MIN0 | 1981 | ⊕ United Kingdom | |||
| Mock Lisp | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ Lazy Evaluation LISPs | ⊕ United States | |
| NAVMAP | 1981 | ||||
| NCRL | 1981 | ||||
| NEPAL | 1981 | ⊕ United Kingdom | |||
| OMEGA | 1981 | ⊕ United States | |||
| OPS6 | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ RETE and production | ⊕ United States | Production system |
| Pam | 1981 | ||||
| PASCAL/M | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ Pascals | ⊕ United Kingdom | Pascal with Modula Modules |
| PCL | 1981 | Programmable Controller Language | |||
| PDL/Ada | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ United States | Program design language based on Ada | |
| PIDGIN | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ United States | CPM/M systems programming language | |
| PIXAL | 1981 | ||||
| PS-ALGOL | 1981 | ↓ ↑ ⊕ Numerical Scientific | ⊕ True ALGOL60s | ⊕ United Kingdom | Persistent Algol |
| PSP | 1981 | ⊕ United States | |||
| RATMAC | 1981 | ⊕ United States | |||
| RBCSP | 1981 | ⊕ United Kingdom | |||
| Relational Language | 1981 | ⊕ United Kingdom | |||
| ROBART 1 | 1981 | ↓ ↑ ⊕ On-Line | ⊕ CAI languages | ⊕ United States | Dialogue grammar based on BNF |
| ROBEX | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Robotics | ⊕ Germany | Robotics dialect of EXAPT |
| Robinson PASCAL | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ Pascals | ⊕ Australia | Proposed extensions to PASCAL |
| ROSIE | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ United States | English-based AI language | |
| S*A | 1981 | ⊕ Canada | high-level architecture description language | ||
| SB-Mod | 1981 | ⊕ United States | |||
| SB-MODULA | 1981 | ↓ ↑ ⊕ Multi-purpose | ⊕ Pascals | ⊕ United States | Development extensions to MODULA |
| SEVAL | 1981 | ↓ ↑ ⊕ Business Data Processing | ⊕ Germany | Data validation language | |
| SL | 1981 | ↓ ↑ ⊕ Experimental and other | ⊕ Tree | ⊕ United States | Structure Language |
| SLIM | 1981 | ||||
| SMP | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Arithmetic | ⊕ United States | |
| SQURL | 1981 | ⊕ United States | |||
| SRL | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Frame languages | ⊕ United States | Schema Representation language |
| Standard Syntactic Metalanguage | 1981 | ||||
| Strand | 1981 | ||||
| STREX | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ United States | String Extended FORTRAN | |
| SUSL | 1981 | ↓ ↑ ⊕ Experimental and other | ⊕ Tree | ⊕ United States | Selective Updating Structure Language |
| TABLET | 1981 | ↓ ↑ ⊕ Business Data Processing | ⊕ United States | ||
| TESI | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ United States | APL for Pictorial Analysis | |
| Thoth | 1981 | ||||
| TINCMP | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ United States | M4 Macro set for PIDGIN | |
| TSL | 1981 | ⊕ United States | |||
| UNBASIC | 1981 | ⊕ United States | |||
| UNIFORM | 1981 | ⊕ Sweden | |||
| UniSolid | 1981 | ⊕ United States | |||
| URL | 1981 | ⊕ United States | |||
| V | 1981 | ↓ ↑ ⊕ Specialised Languages | ⊕ Definition languages | ⊕ United States | |
| V-Compiler | 1981 | ||||
| Y | 1981 | ↓ ↑ ⊕ String and List Processing | ⊕ United States |